The Chiesi Center for Open Innovation & Competence

The Chiesi Center for Open Innovation & Competence (COI&C) is an innovative business playground and an open place for the interaction between Chiesi People and the external stakeholders from the research and continuous innovation fields. It is conceived to implement new ways to identify and develop open innovation projects and educational healthcare-related journeys.

The COI&C is structured as an open collaborative platform, able to nurture and finalize initiatives that will involve external partners and actors, in order to exploit and complement internal expertise with an interdisciplinary approach, while also maximizing the impact of activities at local, national and global level. It contributes to Chiesi business strategy by acting as a supporting service also identifying and opening untapped opportunities with a global reach.

The development of validated and reliable models of the human respiratory system could be of great impact in many sectors:

safety & environment applications related to the inhalation of toxic or carcinogenic aerosols;
healthcare applications e.g. transmission of pathogen agents such as bacteria or viruses;
pharmaceutical product development for prediction and optimization of therapeutic aerosols deposition administered though nose and lungs.

Topics

Simulation and experimental characterization of air dynamics in the lungs;

Modelling therapeutic aerosol generation with DPIs, pMDIs and nebulizers;

Simulation and experimental characterization of aerosol deposition in the lungs;

Lung imaging and its processing; Digital lung models, lung digital twins and their applications in healthcare.

Other industrial applications of lung modelling and simulation include the design of inhalers, nebulizers and vapes. Finally, on a long-term perspective, a digital twin of the human respiratory system could enable the study of lung physiology in extreme conditions or under strong solicitations. The aim of the congress is to gather international experts in these research fields to discuss and challenge the current state of the art and chart a roadmap for future development.

Agenda

Day 1 | 22-11-2023

09:00
Registration and refreshments
10:15 - 10:20
Welcome

Andrea Chiesi
10:20
COI&C/R&D introduction

Dr. F. Conicella

Head of COI&C

T. Eichholtz

Head of R&D
10:40
Developing a multi-scale computational tool for orally inhaled drug product design

Dr. Ciro Cottini

Chiesi Farmaceutici (Parma, Italy)
11:00
The OpenNOSE project: reasons of interest for the lung modelling community

Prof. Maurizio Quadrio

Politecnico di Milano (Milan, Italy)
12:00
Moving towards personalised medicine: A Digital Twin of the Lungs

Prof. Kelly Burrowes

University of Aukland, (Auckland, New Zealand)
13:00
Engineering Lung In-vitro Models

Dr. Ludovica Cacopardo

Università di Pisa (Pisa, Italy)
14:00
Lunch
15:00
Leveling the Playing Field: How Imaging, AI and An Infinite Mindset Can Transform the Care of Patients with Rare Disease

Elizabeth Estes

Open Source Imaging Consortium (Saugatuck MI, USA)
16:00
A critical analysis of CFD-DEM simulation of human airways

Dr. Andrea Benassi

Chiesi Farmaceutici (Parma, Italy)
17:00
Three-dimensional measurements of flow within a patient-specific model of the upper airways using magnetic resonance imaging

Dr. Andrew J. Banko

West Point Military Academy (West Point NY, USA)
18:00
Poster session & Networking with refreshments
19:30 - 22:00
Social dinner (Chiesi Headquarter)

Day 2 | 23-11-2023

09:30
Understanding Human Lung Ventilation through Modeling, Respiratory Mechanics and Imaging

Prof. Andrea Aliverti

Politecnico di Milano (Milan, Italy)
10:30
The role of quantitative imaging in pulmonary drug discovery

Dr. Fabio F. Stellari

Chiesi Farmaceutici (Parma, Italy)
11:30
Coffee Break
12:00
Using lung imaging to inform computations in the context of in-silico population studies

Prof. Stavros Kassinos

University of Cyprus (Nicosia, Cyprus)
13:00
A patient-specific computational model of the entire lung for in silico trials in pulmonary drug delivery

Maximilian Grill

Kei W. Müller

Ebenbuild GmbH (Munich, Germany)
14:00
Lunch
15:00
Laser-optical investigation of aerosol generation and deposition in a 23-generation transparent airway model

Dr. Ing. Manuel Reddemann

Aachen University (Aachen, Germany)
16:00
Enabling the Medical Digital Twin of Human Airways by advanced mesh morphing and high-fidelity patient-specific simulations

Prof. Marco Evangelos Biancolini

Università Tor Vergata (Rome, Italy)
17:00
Closing remarks
17:30 - 19:00
Poster session & Networking with refreshments